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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1

Fig. 2

HUMSCs transplantation improved the amplitude of the compound motor action potentials in SCA1 mice. a Representative recordings of compound motor action potentials generated by the gastrocnemius muscles at 6 months of age for Normal, Normal-PBS, SCA1, SCA1-PBS, and SCA1-HUMSCs mice, showing markedly depressed action potentials in the SCA1 and SCA1-PBS groups and partial recovery by HUMSC transplantation. b Parameters of a schematic compound motor action potential assessed in the study. Quantifications of the mean amplitude, latency, and duration of the compound motor action potentials indicated, in the 6 months old SCA1 and SCA1-PBS mice, significant amplitude depressions which were partially recovered in the SCA1-HUMSCs group (c). However, no statistical differences were found among all the groups with respect to latency (d) and duration (e) recorded. * p < 0.05 compared with the Normal group. ▲ p < 0.05 compared with the Normal-PBS group. # p < 0.05 compared with the SCA1-HUMSCs group

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