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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

Fig. 1

Normal aging is characterized by subclinical SN neuronal decline due to dysregulation in pathways resulting in increased oxidative stress, accumulation of brain iron and neuromelanin, impaired autophagy, accumulation of intracellular α-synuclein and activation of microglia and neuroinflammation. Additional genetic and environmental factors contribute to tip the balance from normal aging to accelerated DA neurodegeneration seen in PD

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