Skip to main content


Fig. 1 | Translational Neurodegeneration

Fig. 1

From: The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

Fig. 1

Normal aging is characterized by subclinical SN neuronal decline due to dysregulation in pathways resulting in increased oxidative stress, accumulation of brain iron and neuromelanin, impaired autophagy, accumulation of intracellular α-synuclein and activation of microglia and neuroinflammation. Additional genetic and environmental factors contribute to tip the balance from normal aging to accelerated DA neurodegeneration seen in PD

Back to article page