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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

Fig. 4

Representative TEM images of RT-QuIC products seeded with OM samples derived from PD and MSA patients. a Measurements of the distance between over-twists in final RT-QuIC fibrils seeded with samples of PD (n = 5) and samples of MSA (n = 5). As shown, the distance between over-twists in α-synuclein fibrils obtained from RT-QuIC products seeded with OM of MSA patients (orange arrows) was about 142 ± 1.3 nm (mean ± standard error of the mean) while that of PD patients (green arrows) was shorter and about 131 ± 1.1 nm and such differences were statistically significant (p < 0.0001, Mann-Withney U test). Scale bar: 35 nm. b TEM images of the same samples taken at higher magnification. Scale bar: 23 nm

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Translational Neurodegeneration

ISSN: 2047-9158

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