Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

Table 1 Clusters of significant FA reduction from WBSS for comparisons TDP-43^G298S vs wt at follow-up, TDP-43^G298S at follow-up vs baseline and ΔFA differences for TDP-43^G298S vs wt. BREGMA coordinates are given in coronal/horizontal/sagittal orientation

No.	Size	BREGMA (cor./hor./sag.)	p	Anatomical localization
Follow-up: TDP-43^G298S vs wt
1	1240	1.3 / -2.6 / 1.5	< 0.000001	M1 and M2
TDP-43^G298S: follow-up vs baseline
2	9696	−1.3 / -1.5 / 0.0	< 0.000001	retrosplenial granular cortex
3	4820	0.0 / -1.5 / 0.0	< 0.000001	cingulate cortex
4	4189	1.3 / -2.6 / 1.5	< 0.000001	M1 and M2
5	4128	−2.1 / -5.6 / -1.5	< 0.000001	posterior thalamic nucleus
Longitudinal: TDP-43^G298S vs wt
6	942	1.2 / -1.5 / 1.5	< 0.000001	agranular insular cortex
7	613	1.2 / -4.6 / -2.5	< 0.000001	M1 and M2

ISSN: 2047-9158