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Table 1 Clusters of significant FA reduction from WBSS for comparisons TDP-43G298S vs wt at follow-up, TDP-43G298S at follow-up vs baseline and ΔFA differences for TDP-43G298S vs wt. BREGMA coordinates are given in coronal/horizontal/sagittal orientation

From: Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

No. Size BREGMA (cor./hor./sag.) p Anatomical localization
Follow-up: TDP-43G298S vs wt
 1 1240 1.3 / -2.6 / 1.5 <  0.000001 M1 and M2
TDP-43G298S: follow-up vs baseline
 2 9696 −1.3 / -1.5 / 0.0 <  0.000001 retrosplenial granular cortex
 3 4820 0.0 / -1.5 / 0.0 <  0.000001 cingulate cortex
 4 4189 1.3 / -2.6 / 1.5 <  0.000001 M1 and M2
 5 4128 −2.1 / -5.6 / -1.5 <  0.000001 posterior thalamic nucleus
Longitudinal: TDP-43G298S vs wt
 6 942 1.2 / -1.5 / 1.5 <  0.000001 agranular insular cortex
 7 613 1.2 / -4.6 / -2.5 <  0.000001 M1 and M2