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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling

Fig. 4

Different approaches of creating human AD cell models. The classical patient-specific approach starts with somatic cells from sAD or fAD patients and healthy control subjects. After reprogramming and differentiation cultures of patient-derived cells are compared to HCS-derived cells. In the monogenic / isogenic approach somatic cells are taken from either fAD patients or healthy controls. Using gene-editing technologies the fAD mutation is corrected or a fAD mutation is introduced into HCS cells. Alternatively, a sAD risk gene can be introduced or modified in HCS cells, such as APOE. After differentiation of into the desired cell type, these modified cells are compered to their isogenic controls, reducing interpatient variation

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