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Table 2 Differential diagnosis of supranuclear gaze palsy and parkinsonism

From: How to spot ocular abnormalities in progressive supranuclear palsy? A practical review

Aetiology Disorders
• Neurodegenerative  • Progressive supranuclear palsy (PSP)
 • Dementia with Lewy body (DLB)
 • Corticobasal degeneration (CBD)
 • Frontotemporal dementia (FTD)
 • Alzheimer’s disease (AD)
• Heredodegenerative  • Kufor Rakeb disease
 • Niemann-Pick disease, type C
 • Perry syndrome
 • Mitochondrial disease (POLG)
 • Dentatorubral pallidoluysian atrophy
 • Gaucher disease
 • Huntington’s disease
 • Wilson’s disease
 • Neuroacanthocytosis
• Vascular  • Vascular-Progressive supranuclear palsy (Vascular-PSP)
 • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
• Infection  • Neurosyphilis
 • Whipple’s disease
• Prion  • Prion’s disease
• Immune-mediated  • Paraneoplastic encephalitis (Anti-Ma1, Anti-Ma2 antibodies)