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Table 2 Differential diagnosis of supranuclear gaze palsy and parkinsonism

From: How to spot ocular abnormalities in progressive supranuclear palsy? A practical review

Aetiology

Disorders

• Neurodegenerative

 • Progressive supranuclear palsy (PSP)

 • Dementia with Lewy body (DLB)

 • Corticobasal degeneration (CBD)

 • Frontotemporal dementia (FTD)

 • Alzheimer’s disease (AD)

• Heredodegenerative

 • Kufor Rakeb disease

 • Niemann-Pick disease, type C

 • Perry syndrome

 • Mitochondrial disease (POLG)

 • Dentatorubral pallidoluysian atrophy

 • Gaucher disease

 • Huntington’s disease

 • Wilson’s disease

 • Neuroacanthocytosis

• Vascular

 • Vascular-Progressive supranuclear palsy (Vascular-PSP)

 • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

• Infection

 • Neurosyphilis

 • Whipple’s disease

• Prion

 • Prion’s disease

• Immune-mediated

 • Paraneoplastic encephalitis (Anti-Ma1, Anti-Ma2 antibodies)