Fig. 1

Sal B and DHM inhibit seeded aggregation of α-syn in a concentration dependent manner. Chemical structures of Sal B (a) and DHM (b) as used throughout the study. Seeded α-syn aggregation can be inhibited by addition of either Sal B (a) or DHM (b) in increasing concentrations. A baseline of ThT fluorescence was captured for both A and B for 3 hours. For both Sal B and DHM, a concentration of 1 μM slows the aggregation kinetics, while higher concentrations lead to a complete inhibition of aggregation process. Graphs are plotted as median of 3 replicates (±95% Confidence Interval)