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Fig. 8 | Translational Neurodegeneration

Fig. 8

From: NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice

Fig. 8

DAT loss in the striatum of c-rel-/- mice occurs before the onset of motor deficits. Representative photomicrographs of DAT positive fibers density in the striatum of wt (a-d) and c-rel-/- mice (e-h) at 5, 7, 12 and 18 months of age. Densitometric analysis of DAT positive fibers is shown in (i-l). The results are expressed as percentage of DAT positive fibers, considering 100% the values obtained for wt mice. Densitometric analysis revealed a significant decrease in the density of DAT positive fibers already in 12-month-old c-rel-/- mice. n = 3 animals per group, ***p<0.001 vs. wt mice, t-test. m Representative immunoblotting of DAT in the striatum of wt and c-rel-/- mice at 4-7, 12 and 18 months. n Densitometric analysis confirmed a significant reduction of DAT levels in c-rel-/- mice starting at 12 months. n = 6 animals per group, **p<0.01 vs. wt mice, t-test

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Translational Neurodegeneration

ISSN: 2047-9158

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