Fig. 6

Progressive α-synuclein accumulation in the OB of c-rel^-/- mice. a, j Nissl-stained coronal sections of OB showing glomerular and granule cell layers, respectively. b-i and (k-r) Representative photomicrographs showing α-synuclein immunoreactivity in the glomerular layer (b-i) and granule cell layer (k-r) from the OB of 5-, 7-, 12- and 18-month-old wt and c-rel^-/- mice. n = 3 animals per group. The arrows indicate α-synuclein signal. c-rel^-/- mice exhibit earlier and stronger expression of α-synuclein in the different layers of the OB when compared to wt mice. Scale bars: in a = 1000 μm for (a, j); in b = 250 μm for (b-i) and (k-r)