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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice

Fig. 4

Progressive α-synuclein accumulation in the LC of c-rel-/- mice. a-j Representative photomicrographs showing α-synuclein/TH double immunofluorescence labeling in 2-, 5-, 7-, 12- and 18-month-old wt and c-rel-/- mice. Alpha-synuclein accumulation in c-rel-/- mice is visible starting from 5 months and increase thereafter. n = 3 animals per group. k-p Representative photomicrographs displaying thioflavin-S/α-synuclein double labeling in 5-, 7- and 12-month-old c-rel-/- mice. The presence of fibrillary aggregated α-synuclein is revealed by the yellow signal in the merge. n = 3 animals per group. q Nissl-stained sections showing the LC area. Scale bars: in a = 50 μm for (a-j); in (k) = 80 μm for (k-p). q = 120 μm

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Translational Neurodegeneration

ISSN: 2047-9158

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