Fig. 3From: NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in miceProgressive α-synuclein accumulation in the DMV of c-rel-/- mice. a-j Representative photomicrographs showing α-synuclein/ChAT double immunofluorescence labeling in 2-, 5-, 7-, 12- and 18-month-old wt and c-rel-/- mice. Please note the earlier appearance and age-related progressive increase of α-synuclein accumulation in the c-rel-/- mice starting from 5 months. n = 3 animals per group. k-p Representative photomicrographs showing thioflavin-S/α-synuclein double labeling in 5-, 7- and 12-month-old c-rel-/- mice. The yellow signal in the merge is indicative of the presence of fibrillary aggregated α-synuclein in the DMV. n = 3 animals per group. q Nissl-stained sections showing the DMV area. Scale bars: in a = 60 μm for (a-j); in (k) = 30 μm for (k-p). q = 120 μmBack to article page