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Table 1 Study metrics for PD and controls as well and diagnostic subgroups

From: No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

Diagnostic group Value Test Comparison P-value PD PD-WOC PD-MCI PD-D All controls
Male n (%) chi2 all PD vs. Controls 0.9747 186 (63) 89 (59) 77 (68) 20 (63) 185 (63)
Mean Sample age in years mean/sd t.test all PD vs. Controls 0.0007 68 ± 7 66 ± 7 69 ± 5 73 ± 6 66 ± 6
Age PD onset mean/sd ANOVA PD-WOC, PD-MCI, PD-D 0.0103 60 ± 9 59 ± 8 61 ± 8 63 ± 10 na
PD duration mean/sd ANOVA PD-WOC, PD-MCI, PD-D 0.0930 8.3 ± 5.9 7.6 ± 5.2 8.7 ± 5.9 9.9 ± 7.7 na
UPDRS III median/mad KW PD-WOC, PD-MCI, PD-D 3.06E-06 21 ± 11.9 18 ± 10.4 22 ± 11.9 31 ± 14.1 na
MMSE median/mad KW PD-WOC, PD-MCI, PD-D 9.34E-12 29 ± 1.5 29 ± 1.5 28 ± 1.5 25 ± 3.0 na
PANDA median/mad KW PD-WOC, PD-MCI, PD-D 3.40E-12 23 ± 5.9 26 ± 4.5 22 ± 4.5 13 ± 7.4 na
Wechsler Memory Scale digit span reverse, number of correct numerical series median/mad KW PD-WOC, PD-MCI, PD-D 3.21E-07 6 ± 1.5 6 ± 1.5 5 ± 1.5 4 ± 3.0 na
Modified Card Sorting Test, Categories completed median/mad KW PD-WOC, PD-MCI, PD-D 4.2E-11 4 ± 1.5 5 ± 1.5 3 ± 1.5 2 ± 1.5 na
Stroop Test reading colours (s) median/mad KW PD-WOC, PD-MCI, PD-D 6.67E-08 36 ± 6.7 32 ± 5.9 38 ± 7.4 49 ± 14.8 na
Stroop Test naming colours (s) median/mad KW PD-WOC, PD-MCI, PD-D 1.11E-06 53 ± 11.9 50 ± 8.9 55 ± 14.1 62 ± 8.9 na
Stroop Test interference (s) median/mad KW PD-WOC, PD-MCI, PD-D 9.71E-09 101 ± 23.7 90 ± 19.3 105 ± 28.9 161 ± 68.9 na
CERAD Trail Making Test A, time to complete (s) median/mad KW PD-WOC, PD-MCI, PD-D 2.31E-13 45 ± 17.8 38 ± 10.4 51 ± 17.8 96 ± 46.7 na
CERAD Trail Making Test B, time to complete (s) median/mad KW PD-WOC, PD-MCI, PD-D 2.31E-13 120 ± 63.8 92 ± 36.3 141.0 ± 67.5 275 ± 37.1 na
CERAD word list memory test, sum score of 3 trails, immediate recall (range 0–30) median/mad KW PD-WOC, PD-MCI, PD-D 4.75E-11 19 ± 4.5 22 ± 4.5 19 ± 4.5 14 ± 5.9 na
CERAD word list, delayed free recall (range 0–10) median/mad KW PD-WOC, PD-MCI, PD-D 5.66E-11 7 ± 3.0 8 ± 1.5 6 ± 3.0 4 ± 1.5 na
Performance Evaluation System for Seniors (LPS 50+) subtest spatial abilities, sum of correct items median/mad KW PD-WOC, PD-MCI, PD-D 3.52E-13 18 ± 7.4 21 ± 4.5 15 ± 7.4 5 ± 4.4 na
NMDA positive n (%) chi2 all PD vs. Controls 0.0032 38(13)/258(87) na na na 65(22)/230(78)
NMDA positive n (%) chi2 PD-WOC, PD-MCI, PD-D 0.8854 na 18(12)/132(88) 16(14)/98(86) 4(13)/28(87) na
NMDA positive n (%) chi2 PD-WOC vs. (PD-MCI + PD-D) 0.6622 na 18(12)/132(88) 20(14)/126(86)   na
NMDA positive n (%) chi2 PD-WOC vs. PD-D 0.9372 na 18(12)/132(88) na 4(13)/28(87) na