Fig. 5
From: Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice
Both CREST +/− and Q394X Mice Display Impaired Motor Coordination. a Behavioral performance of Crest +/− mice (n = 11) and WT littermates (n = 9) in accelerating mode of rotarod tests from 8 rpm to 80 rpm within 300 s from the age of 12 months to 18 months. Tests were performed every two weeks. b Performance of Crest +/− mice (n = 11) and WT littermates (n = 9) in fixed speed mode of rotarod tests at 20 rpm up to 60 s at the age of 18 months. (C and D) The beam walking tests with square beam on Crest +/− mice (n = 11) and WT littermates (n = 9) (c), and on Q394X mice (n = 13) and WT littermates (n = 8) (d) at 18 months of age. The performance was measured by times of hind paw slips (left panel) and the latency to traverse the beam (right panel). Error bars represent SEM. *p < 0.05, **p < 0.01, Student’s t test. ****p < 0.0001, two-way ANOVA