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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

Fig. 3

LDclns inhibited autophagy in ventral midbrain of A53T mice. a-c Representative immunoblotting bands and densitometry analysis of LC3 and p62. The ratio of LC3II/LC3I was significantly decreased in A53T-LDclns mice (genotype, F(1,8) = 16.10, p = 0.0039; ligament, F(1,8) = 1.481, p = 0.2583; interaction, F(1,8) = 12.09, p = 0.0084). LDclns increased levels of p62 in both WT and A53T mice (genotype, F(1,8) = 8.138, p = 0.0214; ligament, F(1,8) = 26.94, p = 0.0008; interaction, F(1,8) = 0.3773, p = 0.5561). Data represent mean ± SEM from 3 mice per group from two independent experiments

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Translational Neurodegeneration

ISSN: 2047-9158

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