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Table 3 Genetic characteristics of patients with Alzheimer’s disease (AD) according to the presence of delusion symptom

From: Hydroxytryptamine transporter gene-linked polymorphic region (5HTTLPR) is associated with delusions in Alzheimer’s disease

  AD-D AD-noD p OR (95% CI) All
5-HTTLPR L/L 80 (46.78%) 15 (17.44%) Reference 95 (36.96%)
5-HTTLPR L/S 64 (37.43%) 53 (61.63%) 0.000 0.226 (0.111–0.459) 117 (45.53%)
5-HTTLPR S/S 27 (15.79%) 18 (20.93%) 0.003 0.281 (0.115–0.682) 45 (17.51%)
HWE p = 0.029 p = 0.029     p = 0.439
5-HTTLPR L 224 (0.655) 83 (0.483) Reference 307 (0.597)
5-HTTLPR S 118 (0.345) 89 (0.517) 0.000 0.491 (0.332–0.726) 207 (0.403)
APOE ε2/ε2
APOE ε2/ε3 8 (4.68%) 7 (8.14%) 0.243 0.486 (0.150–1.586) 15 (5.84%)
APOE ε2/ε4 3 (1.75%) 5 (5.81%) 0.110 0.255 (0.046–1.286) 8 (3.11%)
APOE ε3/ε3 120 (70.18%) 51 (59.30%) Reference 171 (66.54%)
APOE ε3/ε4 39 (22.81%) 21 (24.42%) 0.518 0.789 (0.405–1.544) 60 (23.35%)
APOE ε4/ε4 1 (0.58%) 2 (2.33%) 0.220 0.213 (0.007–3.081) 3 (1.17%)
HWE p = 0.444 p = 0.223     p = 0.057
APOE ε2 11 (0.032) 12 (0.070) 0.041 0.415 (0.166–1.038) 23 (0.045)
APOE ε3 287 (0.839) 130 (0.756) Reference 417 (0.811)
APOE ε4 44 (0.129) 30 (0.174) 0.138 0.664 (0.388–1.139) 74 (0.144)
  1. AD-D AD patients with delusions, AD-noD AD patients without delusions, OR odds ratio, CI confidence interval, 5-HTTLPR 5-hydroxytriptamine transporter gene-linked polymorphic region, APOE apolipoprotein E