GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis

Table 1 Differentially expressed genes (FDR < 0.10)

FC Threshold	Comparison	No. increased	No. decreased	Total
None	6 hours	678	480	1158
	24 hours	726	297	1023
	48 hours	446	107	553
	6–48 hours	1320	799	2119
	Pooled^a	1724	1155	2867
FC > 1.50 or FC < 0.67	6 hours	228	115	343
	24 hours	246	36	282
	48 hours	285	29	314
	6–48 hours	265	30	295
	Pooled^a	634	182	812

^aPooled: Number of genes significantly altered by GM6 (FDR < 0.10) at the indicated FC threshold in any of the 4 comparisons performed (i.e., 6, 24, 48, or 6–48 h)
The table lists the number of differentially expressed genes (DEGs) significantly altered by GM6 in SH-5YSY neuroblastoma cells. All genes were significantly altered at an FDR threshold of 0.10 and we tabulated the number of unique DEGs with and without an additional FC threshold (first column). Differential expression analyses were performed with respect to each time point (6, 24 and 48 h). We additionally identified genes with evidence for a consistent differential expression pattern with respect to each of the 3 time points (6–48 h) as well as genes differentially expressed in any of the 4 comparisons (pooled)

ISSN: 2047-9158