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Table 1 Summary of ReHo studies included in the meta-analysis

From: Alterations of brain local functional connectivity in amnestic mild cognitive impairment

Study Sample (female) Mean Age (SD) MMSE (SD) Education (SD) Scanner strength Software FWHM Threshold Quality scorec
Bai et al., 2008 [31] aMCI 20 (10) 71.3 (3.8) 27.2 (1.6) 14.0 (3.1) GE 1.5 T SPM2, REST 4 mm 0.005, uncorrected 19
HC 20 (11) 69.4 (3.8) 28.3 (1.4) 13.8 (4.0)
Zhang et al., 2010 [11] aMCI 48 (18) 72.04 (4.42) 27 (26–28)d 15.5 (12–16)d GE 1.5 T SPM2, REST 4 mm 0.05, corrected 20
HC 36 (19) 71.64 (3.72) 29 (27–29)d 16 (12–16)d
Liu et al., 2014 [17] aMCI 12 (11) 59.3 (3.3) 26.4 (0.9) 10.5 (1.81) GE 3.0 T SPM5, REST 4 mm 0.01, corrected 20
HC 12 (8) 60.6 (5.8) 29.8 (0.4) 10.6 (2.06)
Cha et al., 2015 [32] aMCI 34 (16) 68.5 (8.0) 27.1 (2.1) 11.5 (5.2) Philips 3.0 T AFNI 6 mm 0.05 corrected 20
HC 62 (45) 68.4 (7.9) 28.6 (1.9) 10.9 (5.2)
Wang et al., 2015 [29] aMCI 30 (12) 69.1 (5.8) 26.2 (2.2) NA Philips 3.0 T SPM8, BRAT 6 mm 0.01, uncorrected 18
HC 32 (17) 70.1 (5.5) 28.1 (1.5) NA
Ni et al., 2016 [14] aMCI 26 (14) 71 (9) 25 (1.48) 12 (3.08) Philips 3.0 T SPM8, REST, DPARSFA 6 mm 0.05, corrected 20
HC 28 (11) 70 (9) 29 (1.09) 15 (1.41)
Long et al., 2016 [10] aMCI 29 (16) 66.55 (8.36) 23.38 (3.03) 10.14 (4.51) Siemens 3.0 T SPM8, REST 4 mm 0.01, corrected 20
HC 33 (21) 62.91 (8.08) 27.94 (1.60) 11.00 (4.12)
Yuan et al., 2016 [13] aMCI 79 (37) 68.16 (6.67) 26.21 (2.69) 12.43 (3.01) Siemens 3.0 T SPM8, REST, DPARSFA 8 mm 0.01, corrected 20
HC 119 (62) 69.65 (7.60) 28.21 (1.46) 11.84 (3.21)
Yuan et al., 2016 [13] aMCI 36 (19) 66.8 (9.5) 24.9 (3.4) 10.0 (4.1) Siemens 3.0 T SPM8, DPARSF 4 mm 0.01, corrected 20
HC 46 (27) 64.3 (7.8) 28.5 (2.0) 11.4 (5.1)
Luo et al., 2018 [28] aMCIa 32 (15) 72.43 (4.25) 28.34 (1.68) 16.47 (2.24) Philips 3.0 T SPM8, REST, DPARSF 6 mm 0.01, corrected 20
aMCIb 32 (15) 74.90 (5.27) 27.16 (1.71) 15.25 (2.65)
HC 49 (31) 73.33 (4.60) 29.02 (1.20) 16.24 (2.60)
  1. Abbreviations: ReHo Regional Homogeneity, aMCI amnestic Mild Cognitive Impairment, SD Standard Deviation, MMSE Mini-Mental State Examination, FWHM Full Width at Half Maximum, SPM Statistical Parametric Mapping, REST the Resting-State fMRI Data Analysis Toolkit, DPARSF Data Processing Assistant for Resting-State fMRI software, DPARSFA DAPRSF Advanced edition, AFNI Analysis of Functional NeuroImages, BRAT Brainnetome fMRI toolkit, NA Not Available, asingle-domain aMCI; bmulti-domain aMCI; ca maximum score of 20 for each study; dreported with median and interquartile range