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Fig. 6 | Translational Neurodegeneration

Fig. 6

From: Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Fig. 6

InRapa recovers mTOR upstream signalling. a Representative WB showing hippocampal p-IRS (Ser307), p-IRS1 (Tyr632) and total IRS1 levels, p-PI3K(Tyr508) and total PI3K levels, p-AKT (Ser473) and total AKT levels, and p-PTEN (Ser380/Thr382/383) and total PTEN, p-AMPK (Ser172) and total AMPK. b Quantification of panel a showing hippocampal levels of PI3K and p-PI3K(Tyr508)/PI3K ratio. c Quantification of panel a showing AKT and p-AKT(Ser473)/AKT ratio. d Quantification of panel a showing levels of PTEN and p-PTEN (Ser380/Thr382/383)/PTEN ratio. e Quantification of panel a showing p-IRS1 (Ser307), p-IRS1 (Tyr632) and total IRS1 levels in Eu and Ts65Dn mice treated with InRapa and Veh. f Quantification of panel a showing AMPK and p-AMPK(Thr172)/AMPK ratio. Densitometry values shown in the bar graph are the mean of 8 samples per each group, normalized per total load and given as percentage of Eu Veh, set as 100%

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