Aberrant functional connectivity network in subjective memory complaint individuals relates to pathological biomarkers

Table 1 The demographic, cognitive and neuropathological information

Variables	NC	SMC	T/χ²- value	P value
Number	40	44
Demographic characteristics
Age, y, mean (SD)	75.10±5.39	73.78±5.81	1.08	0.28
Female, n (%)	22/18	24/20	0.002	0.57
Education (y), mean (SD)	16.70±2.39	16.66±2.60	0.08	0.94
Family, yes/no	23/17	14/30	7.28	0.03*
APOE	27/13	35/9	1.57	0.16
CSF
Aβ_1–42 (pg/ml)	1389.89±755.77	1552.79±683.30	-0.75	0.46
T-Tau (pg/ml)	235.32±83.46	259.52±68.76	-1.05	0.30
P-Tau₁₈₁ (pg/ml)	21.80±8.80	23.50±6.10	-0.73	0.47
Neuropsychiatric Scores
CCI		31.37±8.30
GDS	0.68±0.89	1.14±0.90	-2.36	0.02*
General mental status
MMSE	29.05±1.18	29.36±0.75	-1.44	0.15
Memory function
WMS-LM immediate	15.00±2.67	15.25±3.01	-0.39	0.70
WMS-LM delay	14.38±2.83	14.23±3.40	0.22	0.83
AVLT sum of trials 1–5	44.95±9.43	48.84±9.59	-1.86	0.07
AVLT30	7.18±4.14	8.88±4.18	-1.85	0.07
Attention
Log-transformed TMT-A	1.50±0.12	1.48±0.14	0.59	0.55
Decision-making function
Log-transformed TMT-B	1.79±0.16	1.84±0.17	-1.36	0.18
Language
BNT total	28.94±1.05	28.52±1.50	1.14	0.26
Category fluency	21.75±4.06	22.20±5.02	-0.45	0.65
Visuospatial processing
CDT	4.85±0.36	4.86±0.35	-0.18	0.86
Ecog PT: memory	1.53±0.41	1.94±0.60	-3.73	<0.001*
Ecog PT: global	1.35±0.26	1.55±0.38	-2.85	0.006*
Ecog Inf: memory	1.24±0.40	1.59±0.59	-3.18	0.002*
Ecog Inf: global	1.22±0.34	1.43±0.52	-2.15	0.03*

Data are presented as means ± standard deviations.
Abbreviation: SMC Significant Memory Complaint, NC Normal Controls, GDS Geriatric Depression Scale, MMSE Mini-Mental State Examination, WMS-LM Wechsler Memory Scale Logical Memory, AVLT Auditory Verbal Learning Test, TMT Trail-Making Test, BNT Boston Naming Test, CDT Clock Drawing Test, E-Cog Measurement of Everyday Cognition, PT patient-based, Inf Informant-based;
*p<0.05, significant difference between NC and SMC
Notably: The CSF data in Table 1 only represents the subjects who had CSF sample.

ISSN: 2047-9158