CSF Aβ1–42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorder

Table 4 CSF biomarkers and RBD as predictors of global cognitive decline in PD

Variables (Δ%MoCA as dependent variable)	β	P value
Aβ_1–42 (RBD group)	−0.03 ± 0.01	0.003*
Aβ_1–42 (non-RBD group)	−0.001 ± 0.007	0.944
Group (categorical RBD and non-RBD)	2.95 ± 1.18	0.013*
Aβ_1–42*Group	−2.85 ± 1.15	0.014*

Data are shown as coefficient (β) ± (SE). In these linear effects models, Δ%MoCA is the dependent variable and Aβ_1–42, group and Aβ_1–42*Group are the independent variable, with age, sex, education, ApoE4 status, disease duration and baseline UPDRS part III score as co-variates. *P value statistically significant. Significant interactive effects were observed in Aβ_1–42 and RBD group
Abbreviations: PD Parkinsonr’s disease, RBD Rapid eye movement sleep behavioral disorder, CSF cerebrospinal fluid, MoCA Montreal Cognitive Assessment, Aβ β-amyloid

ISSN: 2047-9158