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Table 3 Baseline CSF biomarkers of PD stratified by RBD

From: CSF Aβ1–42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorder

 

PD with RBD

PD without RBD

P value

 

(N = 136)

(N = 214)

Aβ1–42 (pg/ml)

354.70 ± 103.45

384.73 ± 90.77

0.005*

t-tau (pg/ml)

43.76 ± 18.75

44.42 ± 16.89

0.736

p-tau (pg/ml)

14.57 ± 7.85

16.31 ± 11.32

0.121

alpha-synuclein (pg/ml)

1811.69 ± 741.35

1860.50 ± 818.55

0.578

p-tau/t-tau

0.35 ± 0.17

0.39 ± 0.25

0.130

t-tau/Aβ1–42

0.13 ± 0.07

0.12 ± 0.05

0.056

  1. Results are mean ± (SD). P value was assessed using two-tailed Student t test for each variable. *P value statistically significant. The PD with RBD patients had significantly lower contents of CSF Aβ1–42
  2. Abbreviations: PD Parkinsonr’s disease, RBD Rapid eye movement sleep behavioral disorder, CSF cerebrospinal fluid, t-tau total tau, p-tau phosphorylated-tau, Aβ β-amyloid
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Translational Neurodegeneration

ISSN: 2047-9158

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