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Table 1 Baseline characteristics of PD stratified by RBD

From: CSF Aβ1–42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorder

  PD with RBD PD without RBD P value
(N = 136) (N = 214)
Age, years 61.22 ± 9.44 60.42 ± 9.88 0.447
Males, n(%) 92(67.6%) 137(64.0%) 0.564
Education, year 15.61 ± 2.91 15.57 ± 2.97 0.890
ApoE4(%) 23.40% 24.50% 0.893
RBD 7.04 ± 1.91 2.53 ± 1.17 < 0.001*
Disease duration (months) 7.51 ± 6.69 7.35 ± 6.29 0.816
Hoehn and Yahr Stage 1.57 ± 0.49 1.51 ± 0.52 0.289
UPDRS part III 21.58 ± 9.41 19.63 ± 8.39 0.044*
UPDRS1.1 Cognition, N (% positive) 39(28.7%) 46(21.5%) 0.159
MoCA 26.98 ± 2.40 27.32 ± 2.21 0.170
UPSIT Total 21.60 ± 8.39 22.33 ± 7.96 0.411
Geriatric Depression Scale 5.39 ± 1.94 5.10 ± 1.37 0.065
Total STAI 93.58 ± 8.49 93.33 ± 7.58 0.771
  1. Results are mean ± (SD). P value was assessed using two-tailed Student t test for each variable except gender, ApoE4 and UPDRS1.1, where chi-square (χ2) test was performed. *P value statistically significant. The age, education, ApoE4, disease duration, Hoehn and Yahr Stage, UPDRS1.1 Cognition, MoCA, UPSIT Total, depression and total STAI had no difference between two groups. However, the PD with RBD group had relative greater UPDRS part III
  2. Abbreviations: PD Parkinsonr’s disease, RBD Rapid eye movement sleep behavioral disorder, ApoE4 Apolipoprotein E ɛ4, UPDRS Unified Parkinson’s Disease Rating Scale, MoCA Montreal Cognitive Assessment, UPSIT University of Pennsylvania Smell Identification Test, STAI State Trait Anxiety Inventory