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Table 1 Baseline characteristics of PD stratified by RBD

From: CSF Aβ1–42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorder

 

PD with RBD

PD without RBD

P value

(N = 136)

(N = 214)

Age, years

61.22 ± 9.44

60.42 ± 9.88

0.447

Males, n(%)

92(67.6%)

137(64.0%)

0.564

Education, year

15.61 ± 2.91

15.57 ± 2.97

0.890

ApoE4(%)

23.40%

24.50%

0.893

RBD

7.04 ± 1.91

2.53 ± 1.17

< 0.001*

Disease duration (months)

7.51 ± 6.69

7.35 ± 6.29

0.816

Hoehn and Yahr Stage

1.57 ± 0.49

1.51 ± 0.52

0.289

UPDRS part III

21.58 ± 9.41

19.63 ± 8.39

0.044*

UPDRS1.1 Cognition, N (% positive)

39(28.7%)

46(21.5%)

0.159

MoCA

26.98 ± 2.40

27.32 ± 2.21

0.170

UPSIT Total

21.60 ± 8.39

22.33 ± 7.96

0.411

Geriatric Depression Scale

5.39 ± 1.94

5.10 ± 1.37

0.065

Total STAI

93.58 ± 8.49

93.33 ± 7.58

0.771

  1. Results are mean ± (SD). P value was assessed using two-tailed Student t test for each variable except gender, ApoE4 and UPDRS1.1, where chi-square (χ2) test was performed. *P value statistically significant. The age, education, ApoE4, disease duration, Hoehn and Yahr Stage, UPDRS1.1 Cognition, MoCA, UPSIT Total, depression and total STAI had no difference between two groups. However, the PD with RBD group had relative greater UPDRS part III
  2. Abbreviations: PD Parkinsonr’s disease, RBD Rapid eye movement sleep behavioral disorder, ApoE4 Apolipoprotein E ɛ4, UPDRS Unified Parkinson’s Disease Rating Scale, MoCA Montreal Cognitive Assessment, UPSIT University of Pennsylvania Smell Identification Test, STAI State Trait Anxiety Inventory
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Translational Neurodegeneration

ISSN: 2047-9158

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