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Fig. 7 | Translational Neurodegeneration

Fig. 7

From: Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

Fig. 7

Golgi staining identified the effect of AAV-hm-α-syn injections on neuronal morphology. (a and b) Representative photographs of dendritic protrusions in the substantia nigra. A: 20× magnification. B: 100× magnification in oil immersion. (c) Effect of AAV-hm α-syn on spine density. These results indicated that there was a more significant decrease in spine density in several brain regions in rats injected with AAV-hm-α-syn (vs. control, * means p < 0.05). e Representative photographs of dendritic spines in the SN (100× magnification times in oil immersion). d Effect of AAV-hm-α-syn on the total number of intersection points. The results indicated that there was a significant reduction of the total number of intersection points in different brain regions in rats treated by AAV-hm-α-syn (vs. control, * < 0.05). Data are presented as mean ± SD. *P < 0.05, **P < 0.01. f: Representation diagrams about Goligi staining by AAV & control injection

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