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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

Fig. 4

Effect of AAV-hm-α-syn injection on the number of dopaminergic neurons and DA levels in the striatum-SN. a Presentation of the TH-positive cells in the striatum and SN 12 weeks after injection into the OB. b & c) Comparison of the TH-positive cells in the SN and fibers in the striatum 12 weeks after injection into the OB. These results indicate that the number of TH-positive cells bodies and terminals in the SN-striatum fields is reduced 12 weeks after AAV-hm-α-syn injection. *P < 0.05, **P < 0.01. d & e) Comparison of DA and DOPAC level in the striatum. These results indicate that DA and DOPAC level in the SN-striatum fields is reduced 12 weeks after AAV-hm-α-syn injection. *P < 0.05, **P < 0.01. All data are presented as mean ± SD. (Bar: 20um)

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