|
Model
|
CN vs AD
|
sMCI vs pMCI
|
|---|
|
Correct
|
Correct
|
Correct
|
Correct
|
|---|
|
CN (%)
|
AD (%)
|
sMCI (%)
|
pMCI (%)
|
|---|
|
No covariates
|
|
P-tau only
|
29/32 (90.6%)
|
14/18 (77.8%)
|
11/24 (45.8%)
|
42/47 (89.4%)
|
|
VILIP only
|
29/32 (90.6%)
|
8/18 (44.4%)
|
6/24 (25.0%)
|
43/47 (91.5%)
|
|
YKL-40 only
|
29/32 (90.6%)
|
2/18 (11.1%)
|
0/24 (0%)
|
47/47 (100%)
|
|
P-tau & VILIP
|
29/32 (90.6%)
|
13/18 (72.2%)
|
9/24 (37.5%)
|
39/47 (83.0%)
|
|
P-tau & YKL-40
|
29/32 (90.6%)
|
14/18 (77.8%)
|
10/24 (41.7%)
|
40/47 (85.1%)
|
|
VILIP & YKL-40
|
30/32 (93.8%)
|
8/18 (44.4%)
|
5/24 (20.8%)
|
42/47 (89.4%)
|
|
P-tau & VILIP & YKL-40
|
29/32 (90.6%)
|
14/18 (77.8%)
|
10/24 (41.7%)
|
39/47 (83.0%)
|
|
Adjusted for age, gender, education, and Aβ42
|
|
P-tau only
|
29/32 (90.6%)
|
16/18 (88.9%)
|
10/24 (41.7%)
|
41/47 (87.2%)
|
|
VILIP only
|
27/32 (84.4%)
|
15/18 (83.3%)
|
9/24 (37.5%)
|
41/47 (87.2%)
|
|
YKL-40 only
|
28/32 (87.5%)
|
13/18 (72.2%)
|
10/24 (41.7%)
|
42/47 (89.4%)
|
|
P-tau & VILIP
|
30/32 (93.8%)
|
17/18 (94.4%)
|
12/24 (50%)
|
42/47 (89.4%)
|
|
P-tau & YKL-40
|
30/32 (93.8%)
|
16/18 (88.9%)
|
10/24 (41.7%)
|
42/47 (89.4%)
|
|
VILIP & YKL-40
|
28/32 (87.5%)
|
15/18 (83.3%)
|
9/24 (37.5%)
|
41/47 (87.2%)
|
|
P-tau & VILIP & YKL-40
|
30/32 (93.8%)
|
17/18 (94.4%)
|
11/24 (45.8%)
|
40/47 (85.1%)
|
- Classification tables from logistic regression models using a threshold of 50% for predicted probabilities
- Abbreviations: VILIP-1 Visinin-like protein-1, YKL-40 Chitinase-3-like protein 1, CN cognitively normal, sMCI stable mild cognitive impairment, pMCI progressive mild cognitive impairment, AD Alzheimer’s disease
