Skip to main content

Table 4 The effects of CSF P-tau, VILIP-1, and YKL-40 on classification

From: Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

Model

CN vs AD

sMCI vs pMCI

Correct

Correct

Correct

Correct

CN (%)

AD (%)

sMCI (%)

pMCI (%)

No covariates

 P-tau only

29/32 (90.6%)

14/18 (77.8%)

11/24 (45.8%)

42/47 (89.4%)

 VILIP only

29/32 (90.6%)

8/18 (44.4%)

6/24 (25.0%)

43/47 (91.5%)

 YKL-40 only

29/32 (90.6%)

2/18 (11.1%)

0/24 (0%)

47/47 (100%)

 P-tau & VILIP

29/32 (90.6%)

13/18 (72.2%)

9/24 (37.5%)

39/47 (83.0%)

 P-tau & YKL-40

29/32 (90.6%)

14/18 (77.8%)

10/24 (41.7%)

40/47 (85.1%)

 VILIP & YKL-40

30/32 (93.8%)

8/18 (44.4%)

5/24 (20.8%)

42/47 (89.4%)

 P-tau & VILIP & YKL-40

29/32 (90.6%)

14/18 (77.8%)

10/24 (41.7%)

39/47 (83.0%)

Adjusted for age, gender, education, and Aβ42

 P-tau only

29/32 (90.6%)

16/18 (88.9%)

10/24 (41.7%)

41/47 (87.2%)

 VILIP only

27/32 (84.4%)

15/18 (83.3%)

9/24 (37.5%)

41/47 (87.2%)

 YKL-40 only

28/32 (87.5%)

13/18 (72.2%)

10/24 (41.7%)

42/47 (89.4%)

 P-tau & VILIP

30/32 (93.8%)

17/18 (94.4%)

12/24 (50%)

42/47 (89.4%)

 P-tau & YKL-40

30/32 (93.8%)

16/18 (88.9%)

10/24 (41.7%)

42/47 (89.4%)

 VILIP & YKL-40

28/32 (87.5%)

15/18 (83.3%)

9/24 (37.5%)

41/47 (87.2%)

 P-tau & VILIP & YKL-40

30/32 (93.8%)

17/18 (94.4%)

11/24 (45.8%)

40/47 (85.1%)

  1. Classification tables from logistic regression models using a threshold of 50% for predicted probabilities
  2. Abbreviations: VILIP-1 Visinin-like protein-1, YKL-40 Chitinase-3-like protein 1, CN cognitively normal, sMCI stable mild cognitive impairment, pMCI progressive mild cognitive impairment, AD Alzheimer’s disease