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Table 4 The effects of CSF P-tau, VILIP-1, and YKL-40 on classification

From: Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

Model CN vs AD sMCI vs pMCI
Correct Correct Correct Correct
CN (%) AD (%) sMCI (%) pMCI (%)
No covariates
 P-tau only 29/32 (90.6%) 14/18 (77.8%) 11/24 (45.8%) 42/47 (89.4%)
 VILIP only 29/32 (90.6%) 8/18 (44.4%) 6/24 (25.0%) 43/47 (91.5%)
 YKL-40 only 29/32 (90.6%) 2/18 (11.1%) 0/24 (0%) 47/47 (100%)
 P-tau & VILIP 29/32 (90.6%) 13/18 (72.2%) 9/24 (37.5%) 39/47 (83.0%)
 P-tau & YKL-40 29/32 (90.6%) 14/18 (77.8%) 10/24 (41.7%) 40/47 (85.1%)
 VILIP & YKL-40 30/32 (93.8%) 8/18 (44.4%) 5/24 (20.8%) 42/47 (89.4%)
 P-tau & VILIP & YKL-40 29/32 (90.6%) 14/18 (77.8%) 10/24 (41.7%) 39/47 (83.0%)
Adjusted for age, gender, education, and Aβ42
 P-tau only 29/32 (90.6%) 16/18 (88.9%) 10/24 (41.7%) 41/47 (87.2%)
 VILIP only 27/32 (84.4%) 15/18 (83.3%) 9/24 (37.5%) 41/47 (87.2%)
 YKL-40 only 28/32 (87.5%) 13/18 (72.2%) 10/24 (41.7%) 42/47 (89.4%)
 P-tau & VILIP 30/32 (93.8%) 17/18 (94.4%) 12/24 (50%) 42/47 (89.4%)
 P-tau & YKL-40 30/32 (93.8%) 16/18 (88.9%) 10/24 (41.7%) 42/47 (89.4%)
 VILIP & YKL-40 28/32 (87.5%) 15/18 (83.3%) 9/24 (37.5%) 41/47 (87.2%)
 P-tau & VILIP & YKL-40 30/32 (93.8%) 17/18 (94.4%) 11/24 (45.8%) 40/47 (85.1%)
  1. Classification tables from logistic regression models using a threshold of 50% for predicted probabilities
  2. Abbreviations: VILIP-1 Visinin-like protein-1, YKL-40 Chitinase-3-like protein 1, CN cognitively normal, sMCI stable mild cognitive impairment, pMCI progressive mild cognitive impairment, AD Alzheimer’s disease