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Table 3 Diagnostic accuracy of CSF P-tau, VILIP-1, and YKL-4

From: Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

Groups Model P-tau VILIP-1 YKL-40 AUC (95% CI)
CN vs AD P-tau only 1.177 (p < 0.001)    0.922 (0.847–0.997)b, c, f
VILIP only   1.023 (p = 0.005)   0.753 (0.604–0.903)a, c, d, e, g
YKL-40 only    1.003 (p = 0.112) 0.601 (0.437–0.764)a, b, d, e, f, g
P-tau & VILIP 1.175 (p = 0.001) 1.001 (p = 0.943)   0.922 (0.847–0.997) b, c, f
P-tau & YKL-40 1.178 (p < 0.001) 1.000 (p = 0.921)   0.924 (0.850–0.997) b, c, f
VILIP & YKL-40   1.022 (p = 0.009) 1.000 (p = 0.886) 0.753 (0.604–0.903) a, c, d, e, g
P-tau & VILIP & YKL-40 1.176 (p7 = 0.001) 1.001 (p = 0.912) 1.000 (p = 0.896) 0.924 (0.850–0.997) b, c, f
sMCI vs pMCI P-tau only 1.056 (p = 0.007)    0.708 (0.580–0.836)c
VILIP only   1.011 (p = 0.019)   0.666 (0.5.5–0.797)c
YKL-40 only    1.001 (p = 0.617) 0.524 (0.381–0.667) a, b, d, e, f, g
P-tau & VILIP 1.043 (p = 0.064) 1.006 (p = 0.279)   0.715 (0.591–0.840)c
P-tau & YKL-40 1.061 (p = 0.006)   0.999 (p = 0.544) 0.716 (0.590–0.843)c
VILIP & YKL-40   1.012 (p = 0.020) 0.999(p = 0.741) 0.676 (0.547–0.806)c
P-tau & VILIP & YKL-40 1.047 (p = 0.049) 1.007 (p = 0.231) 0.998 (p = 0.419) 0.727 (0.607–0.847)c
  1. For AUC, the letters a-g indicate significant differences versus other models: P-tau (a), VILIP-1 (b), YKL-40 (c), P-tau & VILIP-1 (d), P-tau & YKL-40 (e), VILIP-1 & YKL-40 (f), P-tau & VILIP-1 & YKL-40 (g). Bold values indicate significant associations
  2. Abbreviations: VILIP-1 Visinin-like protein-1, YKL-40 Chitinase-3-like protein 1, CN cognitively normal, sMCI stable mild cognitive impairment, pMCI progressive mild cognitive impairment, AD Alzheimer’s disease