Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

Table 3 Diagnostic accuracy of CSF P-tau, VILIP-1, and YKL-4

Groups	Model	P-tau	VILIP-1	YKL-40	AUC (95% CI)
CN vs AD	P-tau only	1.177 (p < 0.001)			0.922 (0.847–0.997)^{b, c, f}
	VILIP only		1.023 (p = 0.005)		0.753 (0.604–0.903)^{a, c, d, e, g}
	YKL-40 only			1.003 (p = 0.112)	0.601 (0.437–0.764)^{a, b, d, e, f, g}
	P-tau & VILIP	1.175 (p = 0.001)	1.001 (p = 0.943)		0.922 (0.847–0.997) ^{b, c, f}
	P-tau & YKL-40	1.178 (p < 0.001)	1.000 (p = 0.921)		0.924 (0.850–0.997) ^{b, c, f}
	VILIP & YKL-40		1.022 (p = 0.009)	1.000 (p = 0.886)	0.753 (0.604–0.903) ^{a, c, d, e, g}
	P-tau & VILIP & YKL-40	1.176 (p7 = 0.001)	1.001 (p = 0.912)	1.000 (p = 0.896)	0.924 (0.850–0.997) ^{b, c, f}
sMCI vs pMCI	P-tau only	1.056 (p = 0.007)			0.708 (0.580–0.836)^c
	VILIP only		1.011 (p = 0.019)		0.666 (0.5.5–0.797)^c
	YKL-40 only			1.001 (p = 0.617)	0.524 (0.381–0.667) ^{a, b, d, e, f, g}
	P-tau & VILIP	1.043 (p = 0.064)	1.006 (p = 0.279)		0.715 (0.591–0.840)^c
	P-tau & YKL-40	1.061 (p = 0.006)		0.999 (p = 0.544)	0.716 (0.590–0.843)^c
	VILIP & YKL-40		1.012 (p = 0.020)	0.999(p = 0.741)	0.676 (0.547–0.806)^c
	P-tau & VILIP & YKL-40	1.047 (p = 0.049)	1.007 (p = 0.231)	0.998 (p = 0.419)	0.727 (0.607–0.847)^c

For AUC, the letters a-g indicate significant differences versus other models: P-tau (a), VILIP-1 (b), YKL-40 (c), P-tau & VILIP-1 (d), P-tau & YKL-40 (e), VILIP-1 & YKL-40 (f), P-tau & VILIP-1 & YKL-40 (g). Bold values indicate significant associations
Abbreviations: VILIP-1 Visinin-like protein-1, YKL-40 Chitinase-3-like protein 1, CN cognitively normal, sMCI stable mild cognitive impairment, pMCI progressive mild cognitive impairment, AD Alzheimer’s disease

ISSN: 2047-9158