Table 1 Demographics of subjects

Age, years [mean (SE)]

76.0 (1.0)

76.7 (1.1)

73.1 (1.0)

74.3 (1.6)

Gender, male [n (%)]

19 (59.4%)

17 (70.8%)^d

33 (70.2%)^d

7 (38.9%)

Education, years [mean (SE)]

16.1 (0.6)

16.6(0.5)

15.9 (0.4)

15.2 (0.7)

APOE ε4+ [n (%)]

5 (15.6%)^{c, d}

8 (33.3%)^{c, d}

28 (59.6%)^{a, b}

13 (72.2%)^{a, b}

MMSE at baseline, [mean (SE)]

29.2 (0.2)^{b, c, d}

27.2 (0.3)^{a, d}

26.6 (0.2)^{a, d}

24.2 (0.5)^{a, b, c}

MMSE at 24 m, [mean (SE)]

29.3 (0.2) ^{b, c, d}

26.7 (0.5)^{a, c, d}

24.3 (0.5)^{a, b, d}

18.1 (1.6)^{a, b, c}

Follow-up, years, [mean (SE)]

7.0 (0.4)^{b, c, d}

4.7 (0.5)^{a, d}

5.7 (0.4)^{a, d}

2.6 (0.2)^{a, b, c}