Table 1 Previous Spinal Cord Studies in ALS Using Diffusion Tensor Imaging (DTI)
From: Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice
Research group | Experimental Setup | Diffusion Coefficients | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Author | Year | Animal Models & Subjects | Cohort | MRI instrument | ROI | SC Level | FA | AD | RD | MD |
Gatto et al. [28] | 2018 | B6JL G93A-SOD1 P40 (PS) | G93A-SOD1 (n = 5) WT (n = 5) (Ex-Vivo) | 9.4 T Bruker Agilent | WM(ALF) GM | C,D,L | Decrease(WM) Increase(GM) | Decrease(WM) Increase (GM) | Increase(WM) Decrease(GM) | Increased(WM) Decrease(GM) |
Fukuri et al. [81] | 2017 | Clinical | ALS patients (n = 38) Patient controls (n = 8) | 3 T Siemens MAGNETROM | WM | C5 | Decrease | Not Evaluated | Not Evaluated | Unchanged |
Mancuzzo et al. [15] | 2017 | B6JL G93A-SOD1 P50,P56,P70(PS) & P84,P105,P128 (S) | G93A-SOD1 (n = 7) WT (n = 7) (In-Vivo) | 7 T Bruker BioSpec | D,DR,DL,V,VR,VL | L | Decrease | Unchanged (PS) Decrease (S) | Unchanged | Decrease |
Rasoanandrianina et al. [82] | 2017 | Clinical | ALS patients (n = 10), Patient controls (n = 20) | 3 T Siemens MAGNETROM | WM (CST, PST) GM | C2-C5 | Decrease WM | Decrease(WM) Increase (GM) | Increase(WM) Increase(GM) | Not Evaluated |
Budrewicz et al. [83] | 2016 | Clinical | ALS patients (n = 15), Patient controls (n = 10) | 1.5 T GE Medical systems | ACST,PCST, LCST, GM | C1-C5 | Decrease | Not Evaluated | Not Evaluated | Not Evaluated |
Figini et al. [17] | 2016 | B6JL - G93A-SOD1 P70 (PS) & P119 (S)] | G93A-SOD1 (n = 7) vs WT-SOD1 (n = 7) (In-Vivo) | 7 T Bruker BioSpec | VMT, dT, VLT, DLT, GM | L | Decrease | Unchanged (PS) Decrease (S) | Increase | Increase |
Caron et al. [46] | 2015 | 129Sv G93A-SOD1 P105,P133,P154 (S) & C57 SOD1-G93A P44 (PS); P105,P133,P154 (S) | C57 G93A-SOD1 (n = 6) 129Sv G93A-SOD1(n = 5) WT (n = 6,5) (In-Vivo) & C57 G93A-SOD1 (n = 16) 129Sv G93A-SOD1(n = 16) WT(n = 16) (Ex-Vivo) | 7 T Bruker BioSpec | VMT,VLT,DLT, dT | L | Decrease | Unchanged (PS) Decrease (S) | Increase | Not Evaluated |
Iglesias et al. [84] | 2015 | Clinical | ALS patients (n = 20) Patient controls (n = 19) | 3 T Siemens | PMT, CST | C5- D1 | Decrease | Unchanged | Increase | Increase |
Wang et al. [10] | 2014 | Clinical | ALS patients (n = 24), Patient controls (n = 16) | 1.5 T GE healthcare | ST, LCST | C1-C2 | Decrease | Not Evaluated | Not Evaluated | Not Evaluated |
Romano et al. [85] | 2014 | Clinical | ALS patients (n = 14) Patient controls (n = 14) | 1.5 T Siemens | CST | C,D,L | Decrease | Unchanged | Increase | Increase |
El MendilI et al. [86] | 2014 | Clinical | ALS patients (n = 14) Patient controls (n = 15) | 3 T Siemens Trio | CST | C2 to T6 | Decrease | Unchanged | Increase | Increase |
Cohen- Adad et al. [87] | 2013 | Clinical | ALS patients (n = 29) Patient controls (n = 21) | 3 T Siemens Trio | PSCT, LSCT | C2 to T2 | Decrease | Decrease/Unchanged | Increase | Not Evaluated |
Kim et al. [18] | 2011 | B6JL G93A-SOD1 P84 (S) | G93A-SOD1 (n = 5) WT (n = 5) (In-Vivo) | 4.7 T Oxford Instruments | VLT, dT | C & L | Decrease | Decrease | Increase | Not Evaluated |
Underwood et al. [12] | 2011 | C57 G93A-SOD1 P145 (S) | G93A-SOD1 (n = 6) G93A-SOD1 (n = 6) (In-Vivo) | 16.4 T Bruker | DF,VF,VLF,DLF | D12-L1 | Decrease | Decrease | Increase | Not Evaluated |
Nair et al. [11] | 2010 | Clinical | ALS patients (n = 14) Patient controls (n = 15) | 3 T Siemens Trio | CST | C1-C6 | Decrease | Unchanged | Increase | Increase |
Agosta et al. [30] | 2009 | Clinical | ALS patients (n = 17) Patient controls (n = 20) | 1.5 T Siemens Avanto | CST | C2-C3 | Decrease | Not Evaluated | Not Evaluated | Increase |
Valsalina et al. [88] | 2007 | Clinical | ALS patients (n = 28) Patient controls (n = 20) | 1.5 T Siemens Avanto | CST | C2-C3 | Decrease | Not Evaluated | Not Evaluated | Decrease |
Rossi et al. [89] | 2007 | Clinical | ALS patients (n = 1) Patient controls (n = 8) | 1.5 T and 3 T Scanner | CST | C | Decrease | Not Evaluated | Not Evaluated | Decrease |