Skip to main content

Table 1 Previous Spinal Cord Studies in ALS Using Diffusion Tensor Imaging (DTI)

From: Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice

Research group Experimental Setup Diffusion Coefficients
Author Year Animal Models & Subjects Cohort MRI instrument ROI SC Level FA AD RD MD
Gatto et al. [28] 2018 B6JL G93A-SOD1
P40 (PS)
G93A-SOD1 (n = 5)
WT (n = 5) (Ex-Vivo)
9.4 T Bruker Agilent WM(ALF)
GM
C,D,L Decrease(WM)
Increase(GM)
Decrease(WM)
Increase (GM)
Increase(WM)
Decrease(GM)
Increased(WM)
Decrease(GM)
Fukuri et al. [81] 2017 Clinical ALS patients (n = 38)
Patient controls (n = 8)
3 T Siemens
MAGNETROM
WM C5 Decrease Not Evaluated Not Evaluated Unchanged
Mancuzzo et al. [15] 2017 B6JL G93A-SOD1
P50,P56,P70(PS) & P84,P105,P128 (S)
G93A-SOD1 (n = 7)
WT (n = 7) (In-Vivo)
7 T Bruker BioSpec D,DR,DL,V,VR,VL L Decrease Unchanged (PS) Decrease (S) Unchanged Decrease
Rasoanandrianina et al. [82] 2017 Clinical ALS patients (n = 10),
Patient controls (n = 20)
3 T Siemens
MAGNETROM
WM (CST, PST)
GM
C2-C5 Decrease WM Decrease(WM)
Increase (GM)
Increase(WM)
Increase(GM)
Not Evaluated
Budrewicz et al. [83] 2016 Clinical ALS patients (n = 15),
Patient controls (n = 10)
1.5 T GE Medical systems ACST,PCST, LCST, GM C1-C5 Decrease Not Evaluated Not Evaluated Not Evaluated
Figini et al. [17] 2016 B6JL - G93A-SOD1
P70 (PS) & P119 (S)]
G93A-SOD1 (n = 7) vs
WT-SOD1 (n = 7) (In-Vivo)
7 T Bruker BioSpec VMT, dT, VLT, DLT, GM L Decrease Unchanged (PS) Decrease (S) Increase Increase
Caron et al. [46] 2015 129Sv G93A-SOD1
P105,P133,P154 (S)
&
C57 SOD1-G93A
P44 (PS); P105,P133,P154 (S)
C57 G93A-SOD1 (n = 6)
129Sv G93A-SOD1(n = 5)
WT (n = 6,5) (In-Vivo)
&
C57 G93A-SOD1 (n = 16)
129Sv G93A-SOD1(n = 16)
WT(n = 16) (Ex-Vivo)
7 T Bruker BioSpec VMT,VLT,DLT, dT L Decrease Unchanged (PS) Decrease (S) Increase Not Evaluated
Iglesias et al. [84] 2015 Clinical ALS patients (n = 20)
Patient controls (n = 19)
3 T Siemens PMT, CST C5- D1 Decrease Unchanged Increase Increase
Wang et al. [10] 2014 Clinical ALS patients (n = 24),
Patient controls (n = 16)
1.5 T GE healthcare ST, LCST C1-C2 Decrease Not Evaluated Not Evaluated Not Evaluated
Romano et al. [85] 2014 Clinical ALS patients (n = 14)
Patient controls (n = 14)
1.5 T Siemens CST C,D,L Decrease Unchanged Increase Increase
El MendilI et al. [86] 2014 Clinical ALS patients (n = 14)
Patient controls (n = 15)
3 T Siemens Trio CST C2 to T6 Decrease Unchanged Increase Increase
Cohen- Adad et al. [87] 2013 Clinical ALS patients (n = 29)
Patient controls (n = 21)
3 T Siemens Trio PSCT, LSCT C2 to T2 Decrease Decrease/Unchanged Increase Not Evaluated
Kim et al. [18] 2011 B6JL G93A-SOD1
P84 (S)
G93A-SOD1 (n = 5)
WT (n = 5) (In-Vivo)
4.7 T Oxford Instruments VLT, dT C & L Decrease Decrease Increase Not Evaluated
Underwood et al. [12] 2011 C57 G93A-SOD1
P145 (S)
G93A-SOD1 (n = 6)
G93A-SOD1 (n = 6) (In-Vivo)
16.4 T Bruker DF,VF,VLF,DLF D12-L1 Decrease Decrease Increase Not Evaluated
Nair et al. [11] 2010 Clinical ALS patients (n = 14)
Patient controls (n = 15)
3 T Siemens Trio CST C1-C6 Decrease Unchanged Increase Increase
Agosta et al. [30] 2009 Clinical ALS patients (n = 17)
Patient controls (n = 20)
1.5 T Siemens Avanto CST C2-C3 Decrease Not Evaluated Not Evaluated Increase
Valsalina et al. [88] 2007 Clinical ALS patients (n = 28)
Patient controls (n = 20)
1.5 T Siemens Avanto CST C2-C3 Decrease Not Evaluated Not Evaluated Decrease
Rossi et al. [89] 2007 Clinical ALS patients (n = 1)
Patient controls (n = 8)
1.5 T and 3 T Scanner CST C Decrease Not Evaluated Not Evaluated Decrease
  1. Summary of previous studies using DTI to investigate microstructural changes in ALS spinal cord
  2. Abbreviations: FA Fractional Anisotropy SC Spinal Cord, C Cervical segment, D Dorsal segment, L Lumbar segment, RD Radial Diffusion, AD Axial Diffusion, MD Mean Diffusion, ROI Region of interest, CST Corticospinal Tracts, LCST Lateral Corticospinal Tracts, PCST Posterior Corticospinal Tract, ACST Anterior Corticospinal Tract, CMG Central Grey matter, ST Spinothalamic Tract, PMT Posterior Medial Tract, CMG Central Grey Matter, ST Spinothalamic Tracts, PMT Posterior Medial Tract, VMT Ventromedial Tract, PS Presymptomatic, S Symptomatic, dT Dorsal Tract, VLT Ventrolateral Tract, DLT Dorsolateral Tract, DF Dorsal Funiculi, VF Ventral Funiculi, VLF Ventrolateral Funiculi, DLF Dorsolateral Funiculi.[Source: PubMed. Key words: ALS / DTI /Spinal Cord /Diffusion Tensor imaging]