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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice

Fig. 4

Presymptomatic white matter fiber from the YFP, G93A-SOD1 mice are associated to quantitative changes in axonal connectivity. a Quantitative analysis of Fractional Anisotropy (FA), Axial Diffusion (AD) and Radial Diffusion (RD) from spinal cord (SC) white matter (WM) showing a significant decrease in FA and AD and an increase in RD in the YFP, G93A-SOD1 (ALS) mice compared with controls (*p < 0.05) (**p < 0.01), (***p < 0.001) (n = 4/5). b Statistical analysis of Edge Weight analysis from ROIs showing statistical differences in presymptomatic (P80) WM connectivity in the YFP, G93A-SOD1 mice compared with controls. (* = p < 0.05), (** = p < 0.01). Abbreviations: YFP, yellow fluorescent protein; P80, postnatal day 80 (presymptomatic)

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