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Table 2 Substantia nigra sonography findings indicating non-TD PD rather than MSA-P

From: The role of substantia nigra sonography in the differentiation of Parkinson’s disease and multiple system atrophy

  Total patients Patients with disease duration ≤3 years
  SNL ≥ 18 mm2 SNL ≥ 25 mm2 SNL ≥ 18 mm2 SNL ≥ 25 mm2
Sensitivity, % 74.1 46.3 69.8 41.3
Specificity, % 61.6 80.2 52.2 73.9
PPV, % 76.8 80.0 66.7 68.4
NPV, % 58.2 46.6 55.8 47.9
  1. Non-TD PD non-tremor dominant Parkinson’s disease, MSA-P multiple system atrophy with predominant parkinsonism, SNL the larger value of bilateral SN hyperechogenicity, PPV positive predictive value, NPV negative predictive value