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Table 5 Meta-regression analyses

From: Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer’s dementia: a meta-analysis

  Anatomical label Peak MNI coordinate (x, y, z) Number of voxels SDM-Z value p value
Effect of age Association of regional glucose metabolism effect size and older mean age of aMCI converters
  Left middle temporal gyrus (BAs 21 and 20) −54, 4, − 28 152 −1.64 0.00024
  Left middle temporal gyrus (BA 37) −56, −58, −2 64 −1.69 0.00016
  Left superior /middle frontal gyri, orbital part (BA 11) −18, 58, − 14 53 1.73 0.000076
Effect of illness severity Association of regional glucose metabolism effect size and lower mean MMSE scores of aMCI converters
  Left middle frontal gyrus (BA 9) −24, 22, 42 21 −2.74 0.00014
  Left temporal pole (BAs 28 and 36) −20, 8, −34 13 −2.69 0.00017
Effect of follow-up duration Association of regional glucose metabolism effect size and longer mean follow-up duration
  Left middle frontal gyrus (BAs 46 and 9) −30, 40, 30 255 −3.30 0.000037
  1. Abbreviations: SDM Seed-based d Mapping, MNI Montreal Neurological Institute, aMCI amnestic mild cognitive impairment, PCC posterior cingulate cortex, ACC anterior cingulate cortex, BA Brodmann area