Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer’s dementia: a meta-analysis

Table 2 Clusters of regional hypometabolism in aMCI converters relative to aMCI non-converters

Anatomical label	Peak MNI coordinate (x, y, z)	Number of voxels	SDM-Z value	p value (SDM)	p value (Egger’s test)
Left/Right PCC/precuneus (BAs 23, 7, and 30)	−4, −48, 28	1959	−2.73	~ 0	0.37
Left/Right ACC (BAs 11, 32, 24, and 10)	−4, 32, 0	668	−1.72	0.00047	0.23
Left middle temporal gyrus (BAs 21, 20, and 38)	−44, 4, − 26	501	−1.66	0.00067	0.16
Left middle temporal gyrus (BAs 21 and 37)	−58, −52, −2	185	− 1.65	0.00074	0.13
Left middle frontal gyrus, orbital part (BA 11)	−20, 40, −18	22	−1.39	0.0031	0.30

Abbreviations: MCI amnestic mild cognitive impairment, MNI Montreal Neurological Institute, SDM Seed-based d Mapping, PCC posterior cingulate cortex, ACC anterior cingulate cortex, BA Brodmann area

ISSN: 2047-9158