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Table 1 Characteristics of FDG-PET studies included in the meta-analysis

From: Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer’s dementia: a meta-analysis

Study Sample size (female) Age (SD) Education (years) MMSE (SD) Software FWHM Threshold Follow-up Duration Diagnostic Criteria
Chetelat et al., 2003 [14] Converters 7 (4) 73 (5.1) NA 26.3 (1) SPM99 NA 0.05, corrected 18 months Petersen et al. (2001) [37]
Non-converters 10 (5) 67.8 (7) NA 27.8 (1.2)  
Drzezga et al., 2003 [21] Converters 8 (3) 71.6 (4.3) NA 27.9 (1.2) SPM99 12 mm 0.001, uncorrected 12 months Petersen et al. (1999) [38]
Non-converters 12 (7) 68.6 (6.5) NA 28.1 (1.3)  
Mosconi et al., 2004 [15] Converters 8 (NA) 71 (5) 8 (3) 26.7 (1.3) SPM99 12 mm 0.05, corrected 12.0 months Petersen et al. (2001) [37]
Non-converters 29 (NA) 66 (8) 10 (5) 28.3 (1.4) 12.1 months
Salmon et al., 2008 [19] Converters 17 (12) 71.3 (5.9) 10.8 (2.5) 24.0 (2.2) SPM2 12 mm 0.005, uncorrected 36 months Petersen et al. (2001) [37] and Winblad et al. (2004) [39]
Non-converters 17 (7) 66.2 (7.0) 12.3 (5.2) 25.7 (1.9)  
Fouquet et al., 2009 [23] Converters 7 (5) 73.3 (4.3) 11.0 (4.7) 26.7 (1.0) SPM2 10 mm 0.005, uncorrected 17.5 months Petersen et al. (2001) [37]
Non-converters 10 (6) 70.4 (11.2) 9.9 (3.6) 28.1 (1.0) 18.2 months
Kim et al., 2010 [20] Convertersa 7 (NA) 57.8 (3.7) NA 27.00 (1.15) SPM2 12 mm 0.001, uncorrected 60 months Petersen et al. (1999) [38]
Non-convertersa 5 (NA) 60.0 (4.2) NA 28.00 (2.12)  
Kim et al., 2010 [20] Convertersb 8 (NA) 71.7 (4.4) NA 27.50 (1.87) SPM2 12 mm 0.001, uncorrected 60 months Petersen et al. (1999) [38]
Non-convertersb 6 (NA) 75.8 (4.1) NA 26.63 (1.69)  
Morbelli et al., 2010 [22] Converters 9 (7) 77.1 (5.9) 8.6 (4.3) 27.8 (0.9) SPM2 10 mm 0.005, uncorrected 22.6 months Petersen et al. (2004) [40]
Non-converters 11 (5) 74.0 (5.3) 8.7 (4.5) 27.8 (1.4) 26.5 months
Pagani et al., 2010 [16] Converters 10 (8) 77.7 (4.8) 8.8 (3.9) 27.5 (1.4) SPM2 8 mm 0.05, corrected 22.0 months Petersen et al. (2004) [40]
Non-converters 9 (4) 75.8(5.9) 11.0 (5.3) 27.0 (2.0) 23.7 months
Sohn et al., 2015 [45] Converters 12 (9) 69.5 (7.7) 7.5 (2.9) 19.9 (3.5) SPM8 12 mm 0.005, uncorrected 24 months Albert et al. (2011) [41]
Non-converters 20 (14) 71.6 (7.0) 9.2 (4.1) 23.9 (3.4)  
  1. Abbreviations: FDG-PET 18F-fluorodesoxyglucose positron emission tomography, SD standard deviation, MMSE Mini-Mental State Examination, FWHM full width at half maximum, NA not available, SPM statistical parametric mapping
  2. aearly-onset amnestic mild cognitive impairment
  3. blate-onset amnestic mild cognitive impairment