Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer’s dementia: a meta-analysis

Ma, Hai Rong; Sheng, Li Qin; Pan, Ping Lei; Wang, Gen Di; Luo, Rong; Shi, Hai Cun; Dai, Zhen Yu; Zhong, Jian Guo

doi:10.1186/s40035-018-0114-z

Table 1 Characteristics of FDG-PET studies included in the meta-analysis

From: Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer’s dementia: a meta-analysis

Study	Sample size (female)		Age (SD)	Education (years)	MMSE (SD)	Software	FWHM	Threshold	Follow-up Duration	Diagnostic Criteria
Chetelat et al., 2003 [14]	Converters	7 (4)	73 (5.1)	NA	26.3 (1)	SPM99	NA	0.05, corrected	18 months	Petersen et al. (2001) [37]
Chetelat et al., 2003 [14]	Non-converters	10 (5)	67.8 (7)	NA	27.8 (1.2)	SPM99	NA	0.05, corrected		Petersen et al. (2001) [37]
Drzezga et al., 2003 [21]	Converters	8 (3)	71.6 (4.3)	NA	27.9 (1.2)	SPM99	12 mm	0.001, uncorrected	12 months	Petersen et al. (1999) [38]
Drzezga et al., 2003 [21]	Non-converters	12 (7)	68.6 (6.5)	NA	28.1 (1.3)	SPM99	12 mm	0.001, uncorrected		Petersen et al. (1999) [38]
Mosconi et al., 2004 [15]	Converters	8 (NA)	71 (5)	8 (3)	26.7 (1.3)	SPM99	12 mm	0.05, corrected	12.0 months	Petersen et al. (2001) [37]
Mosconi et al., 2004 [15]	Non-converters	29 (NA)	66 (8)	10 (5)	28.3 (1.4)	SPM99	12 mm	0.05, corrected	12.1 months	Petersen et al. (2001) [37]
Salmon et al., 2008 [19]	Converters	17 (12)	71.3 (5.9)	10.8 (2.5)	24.0 (2.2)	SPM2	12 mm	0.005, uncorrected	36 months	Petersen et al. (2001) [37] and Winblad et al. (2004) [39]
Salmon et al., 2008 [19]	Non-converters	17 (7)	66.2 (7.0)	12.3 (5.2)	25.7 (1.9)	SPM2	12 mm	0.005, uncorrected		Petersen et al. (2001) [37] and Winblad et al. (2004) [39]
Fouquet et al., 2009 [23]	Converters	7 (5)	73.3 (4.3)	11.0 (4.7)	26.7 (1.0)	SPM2	10 mm	0.005, uncorrected	17.5 months	Petersen et al. (2001) [37]
Fouquet et al., 2009 [23]	Non-converters	10 (6)	70.4 (11.2)	9.9 (3.6)	28.1 (1.0)	SPM2	10 mm	0.005, uncorrected	18.2 months	Petersen et al. (2001) [37]
Kim et al., 2010 [20]	Converters^a	7 (NA)	57.8 (3.7)	NA	27.00 (1.15)	SPM2	12 mm	0.001, uncorrected	60 months	Petersen et al. (1999) [38]
Kim et al., 2010 [20]	Non-converters^a	5 (NA)	60.0 (4.2)	NA	28.00 (2.12)	SPM2	12 mm	0.001, uncorrected		Petersen et al. (1999) [38]
Kim et al., 2010 [20]	Converters^b	8 (NA)	71.7 (4.4)	NA	27.50 (1.87)	SPM2	12 mm	0.001, uncorrected	60 months	Petersen et al. (1999) [38]
Kim et al., 2010 [20]	Non-converters^b	6 (NA)	75.8 (4.1)	NA	26.63 (1.69)	SPM2	12 mm	0.001, uncorrected		Petersen et al. (1999) [38]
Morbelli et al., 2010 [22]	Converters	9 (7)	77.1 (5.9)	8.6 (4.3)	27.8 (0.9)	SPM2	10 mm	0.005, uncorrected	22.6 months	Petersen et al. (2004) [40]
Morbelli et al., 2010 [22]	Non-converters	11 (5)	74.0 (5.3)	8.7 (4.5)	27.8 (1.4)	SPM2	10 mm	0.005, uncorrected	26.5 months	Petersen et al. (2004) [40]
Pagani et al., 2010 [16]	Converters	10 (8)	77.7 (4.8)	8.8 (3.9)	27.5 (1.4)	SPM2	8 mm	0.05, corrected	22.0 months	Petersen et al. (2004) [40]
Pagani et al., 2010 [16]	Non-converters	9 (4)	75.8(5.9)	11.0 (5.3)	27.0 (2.0)	SPM2	8 mm	0.05, corrected	23.7 months	Petersen et al. (2004) [40]
Sohn et al., 2015 [45]	Converters	12 (9)	69.5 (7.7)	7.5 (2.9)	19.9 (3.5)	SPM8	12 mm	0.005, uncorrected	24 months	Albert et al. (2011) [41]
Sohn et al., 2015 [45]	Non-converters	20 (14)	71.6 (7.0)	9.2 (4.1)	23.9 (3.4)	SPM8	12 mm	0.005, uncorrected		Albert et al. (2011) [41]

Abbreviations: FDG-PET ¹⁸F-fluorodesoxyglucose positron emission tomography, SD standard deviation, MMSE Mini-Mental State Examination, FWHM full width at half maximum, NA not available, SPM statistical parametric mapping
^aearly-onset amnestic mild cognitive impairment
^blate-onset amnestic mild cognitive impairment

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ISSN: 2047-9158

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