Fig. 3
From: Factors that influence adult neurogenesis as potential therapy
Influence of Notch and WNT signaling on neurogenesis. Wnt signaling enhances NSCs differentiation through the transcriptional upregulation of NeuroD1 and inhibiting Sox2 from restraining NeuroD1 expression. Upon aging WIP1 is downregulated and allow DKK3 to inhibit Wnt signaling that results in reduced NeuroD1 levels and NSC differentiation. In contrast, Sox2, downstream Notch signaling, enhances NSC proliferation. TLX alters the expression of cell cycle regulators as pten, p57, and p21 and induces NSC proliferation