Fig. 2
From: Factors that influence adult neurogenesis as potential therapy
Factors upregulating neurotrophins. BDNF levels and consequently initiate NSC proliferation via activation of the TrkB receptor, which later differentiates into dopaminergic neurons (a). NGF, through its downstream receptor TrkA, initiates NSC proliferation that results in cholinergic neurons formation (b). The dopaminergic and cholinergic neuronal differentiation occurs primarily during developmental neurogenesis, however, environmental factors, stem cell transplantation, and anti-inflammatory drugs could potentially induce these processes in adult neurogenesis