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Table 4 Physiological functions of H2S based on its neuroprotective and neuromodulatory effects

From: Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Mode of physiological functions of H2S Evidences
Neuroprotection PD: Inhibits oxygen consumption and 6-hydroxydopamine evoked NADPH oxidation.
Acts on various protein kinases.
HD: Upregulation of GSH enzyme and reveals the learning and memory problem.
AD: Decreases protein oxidation and lipid peroxidation.
 Reduces homocysteine-induced toxicity.
 Influences synaptic remodelling.
ALS: Proper regulation of GSH enzyme and reduction of oxidative stress.
TBI: Protection via apoptotic and autophagic pathway.
Protective effects against neuropathic pain and brain edema.
Neuromodulation  • Long term potentiation.
 • CFTR Cl and KATP cycle regulation.
 • Enhancement of NMDA receptor activity.
 • Regulation of intracellular Ca2+.