Skip to main content
Fig. 6 | Translational Neurodegeneration

Fig. 6

From: RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA

Fig. 6

Mechanism of TFEB at the PGC1-a promoter. The PGC1a promoter contains a CLEAR-box that is known to be bound by TFEB, a transcription factor induced during autophagy and lysosomal biogenesis. A construct being the PGC1a promoter CLEAR-box would be induced by TFEB under conditions of intracellular proteotoxicity due to HTT aggregation. By this mechanism, on-demand suppression of HTT could be achieved

Back to article page
\