Fig. 2From: The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targetsBrain glymphatic pathway facilitates the drainage of excess Aβ in CSF and ISF. CSF can flows into perivascular space through Virchow-Robin space, and then enters into brain parenchyma mixing with extracellular ISF. The CSF and ISF can travel along the arterial and capillary membrane then flow into leptomeningeal blood vessels or subarachnoid space, or move to cervical lymphnodes by lymphatic drainage and finally flow into blood. The higher expression of AQP4 surrounding veins provides an arteriovenous hydrostatic gradient to drive glymphatic drainageBack to article page