Table 1 Genetic characteristics of familial and sporadic ALS

Proportion

10%

90%

Disease category

Monogenic

Complex

Inheritance

Autosomal dominant (most common) Recessive

X-linked

Gene-environment interactions

Gene-gene interactions

Autosomal recessive variants

De novo variants

Common genes (% mutations)

C9orf72 repeat expansions (24%)

SOD1 (20%)

TARDBP (1–5%)

FUS (1–5%)

Other genes (rare or unknown)

C9orf72 repeat expansions (5–10%)

SOD1 (1–3%)

Other genes (rare or unknown)