Skip to main content

Table 2 Potential neurophysiological tests for tremor differential diagnosis

From: Rest tremor revisited: Parkinson’s disease and other disorders

Techniques Diagnostic reliability Design Parkinsonian tremor Essential tremor Dystonic tremor Psychogenic tremor References
Mean hormonic peak power Accuracy 94% Tremulous PD(n = 39) vs. ET(n = 41) Tremulous PD > ET - - Muthuraman M. Mov Disord. 2011 [47]
Coherence entrainment test (CET) Accuracy 100% Psychogenic trmeor (n = 10) vs. DT (n = 11) vs. HC(n = 10) - - negative positive McAuley J. Mov Disord. 2004 [50]
Blink reflex recovery curve (BRrc) Accuracy 100% DT(n = 10) vs. ET(n = 10) vs. HC(n = 12) - Normal Increased R2 recovery index - Nistico R. Neurology. 2012 [51]
  Accuracy 100% tPD(n = 11) vs. ET with rest tremor(n = 10) vs. HC(n = 20) Incresed R2 component Normal at ISI 100 - - Nistico R. Parkinsonism Relat. Disord. 2014 [52]
Temporal discrimination movement threshold (TDMT) PPV 86.7%, NPV 70.8% ET(n = 19) vs. TAD(n = 20) VS. HC(n = 25) - Higher Normal - Tinazzi M. Neurology. 2013 [53]
Somatosensory Temporal discrimination threshold (TDT) PPV 100.0%, NPV 74.1% TAD (n = 20) vs. ET(n = 19) VS. HC(n = 25) - Normal Higher - Tinazzi M. Neurology. 2013 [53]
Reciprocal inhibition (RI) Not given CD with arm tremor(n = 13) vs. ET(n = 8) - Normal Partially reduced - Munchau L. Brain. 2001 [54]
  1. TAD Tremor associated with dystonia, DT dystonic tremor, CD cervical dystonia, tPD tremor dominant PD, PPV positive predictive value, NPV negative predictive value, ISI interstimulus intervals, -, not given