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Table 4 Factors that modify the predictive effects of levodopa responsiveness and disease subtype on motor improvement

From: Factors predicting the instant effect of motor function after subthalamic nucleus deep brain stimulation in Parkinson’s disease

Predictors

Stratification factors

 

β

95% CI

P value

Preoperative levodopa responsiveness

Gender

Female

1.1a

(0.3,1.9)

0.0294*

Male

0.6a

(−0.4,1.6)

0.2901

Disease duration, y

<10

2.0a

(1.1,2.9)

0.0021**

> = 10

−0.1a

(−0.9,0.8)

0.8874

Motor fluctuations duration, y

<=3

3.1a

(0.8,5.5)

0.0393*

>3

0.5a

(−0.4,1.3)

0.3061

Disease subtype(PIGD/LPS)

Motor fluctuations duration, y

>3

−38.4b

(−67.1,−9.7)

0.039*

Disease severity

>50

−41.1b

(−61.8,−20.4)

0.03*

  1. arefers to the value of β means that as each increase of 1% of Levodopa responsiveness, the postoperative motor function improved as a certain amplitude; brefers to the value of β means the difference of motor improvement of PIGD group compared to that of LPS group; **p < 0.01, *p < 0.05; Disease severity was measured by the baseline UPDRS scores of part III