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Table 4 Kinetics of the enzyme activity in full-length KGA and its N-terminal deletion mutants

From: Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

Protein

Km (mM)

Vmax (μmol/min per ml)

KGA FL

21.23 ± 3.57

30.50 ± 2.18

KGA 111–669 AA

27.37 ± 2.80

34.15 ± 1.64

KGA 219–669 AA

36.61 ± 8.70

41.39 ± 5.19

KGA 311–669 AA

0.43 ± 0.28

0.82 ± 0.03

KGA 415–669 AA

1.00e-007 ± 0.21

0.65 ± 0.02

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Translational Neurodegeneration

ISSN: 2047-9158

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