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Table 3 Kinetics of the enzyme activity in full-length GAC and its N-terminal deletion mutants

From: Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

Protein

Km (mM)

Vmax (μmol/min per ml)

GAC FL

27.44 ± 4.92

37.65 ± 3.18

GAC 111–598 AA

34.30 ± 3.88

41.24 ± 2.4

GAC 219–598 AA

19.77 ± 3.17

3 1.61 ± 2.14

GAC 311–598 AA

0.51 ± 0.29

0.78 ± 0.03

GAC 415–598 AA

1.00e-007 ± 0.19

0.52 ± 0.02

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Translational Neurodegeneration

ISSN: 2047-9158

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