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Table 1 Misfolded proteins associated with neurodegenerative diseases

From: Protein misfolding in neurodegenerative diseases: implications and strategies

Proteinopathy Aggregating protein(s)
Alzheimer’s disease Amyloid beta (Ab) peptide; Tau
Parkinson’s disease α-synuclein
Multiple tauopathies Tau protein (microtubule associated)
Huntington’s disease Huntingtin with tandem glutamine repeats
Amyotrophic lateral sclerosis Superoxide dismutase 1
Spongiform encephalopathies Prion proteins
Familial amyloidotic polyneuropathy Transthyretin (mutant forms)