Fig. 4

PEG delayed the onset of motor deficits. Comparison of onset of symptoms between EAE (saline-treated, n = 12) and EAE + PEG (EAE-treated with PEG, n = 11) groups. The graph represents the temporal distribution or symptom onset for EAE and EAE + PEG mice. The number of mice showing initial symptoms was recorded daily for each group. Symptom onset for EAE mice was tightly clustered early in the study while onset for EAE + PEG mice was more dispersed. The inset graph represents the average day of onset for EAE and EAE + PEG groups. Animals in EAE + PEG group developed symptoms significantly later in the study compared to EAE mice (P < 0.01). Three mice in the EAE + PEG-group never developed symptoms and were counted as day 28 for both graphs