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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs

Fig. 2

Chemical structures of compound AZD-3293. a AZD-3289 is a potent BACE1 inhibitor with a chemical formula of C26H28N4O and a structure name of (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine. It’s molecular weight is 449. b AZD-3293 is developed at AstraZeneca and Astex with a chemical formula of C26H28N4O and structural name of 4-Methoxy-5′′-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazole]-4′′-amine. It’s molecular weight is 412. 54

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