|
Variable
|
Control group (range)
|
AD group (range)
|
Mean difference (CI)
|
p
|
|---|
|
Number
|
10
|
10
| | |
|
Gender (female/male)
|
4/6
|
6/4
| |
n.s.
|
|
Age (years)
|
69.4 (54–79)
|
70.0 (56–82)
|
0.6 (−8.7;9.8)
|
n.s.
|
|
Duration (years)
|
2.8 (1.0-5.5)
|
2.3 (1.5-4.0)
|
−0.5 (−1.9;0.9)
|
n.s.
|
|
MMSE
|
24.1
|
21.4
|
−2,7 (−8.1;2.7)
|
n.s.
|
|
ACE
|
75.4
|
67.3
|
−8.1 (−18.0;1.7)
|
n.s.
|
|
Aβ1-42 [pg/ml CSF]
|
561.4 (315–865)
|
391.6 (242–755)
|
−169.8 (−330.0;-9.6)
|
0.04
|
|
Total tau [pg/ml CSF]
|
481.4 (228–1200)
|
540.6 (371–742)
|
59.2 (−223.3;341.7)
|
n.s.
|
|
P-tau [pg/ml CSF]
|
60.1 (31–148)
|
82.6 (55–110)
|
22.5 (−3.2;48.2)
|
n.s.
|
-
Control group patients diagnosed with vascular dementia (n = 4), frontotemporal dementia (n = 4), and dementia with Lewy bodies (n = 2). AD group patients all diagnosed with Alzheimer’s dementia. MMSE Mini-Mental State Examination score, ACE Addenbrooke’s Cognitive Examination score. Mean difference [CI] difference of mean values between groups and 95 % confidence interval of the difference. p p-values of difference calculated by two-sided t-tests or Fisher’s exact test (Gender), n.s. nonsignificant (p > 0.05)
