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Table 1 Demographic data of the patients included

From: miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia – an exploratory study

Variable Control group (range) AD group (range) Mean difference (CI) p
Number 10 10   
Gender (female/male) 4/6 6/4   n.s.
Age (years) 69.4 (54–79) 70.0 (56–82) 0.6 (−8.7;9.8) n.s.
Duration (years) 2.8 (1.0-5.5) 2.3 (1.5-4.0) −0.5 (−1.9;0.9) n.s.
MMSE 24.1 21.4 −2,7 (−8.1;2.7) n.s.
ACE 75.4 67.3 −8.1 (−18.0;1.7) n.s.
Aβ1-42 [pg/ml CSF] 561.4 (315–865) 391.6 (242–755) −169.8 (−330.0;-9.6) 0.04
Total tau [pg/ml CSF] 481.4 (228–1200) 540.6 (371–742) 59.2 (−223.3;341.7) n.s.
P-tau [pg/ml CSF] 60.1 (31–148) 82.6 (55–110) 22.5 (−3.2;48.2) n.s.
  1. Control group patients diagnosed with vascular dementia (n = 4), frontotemporal dementia (n = 4), and dementia with Lewy bodies (n = 2). AD group patients all diagnosed with Alzheimer’s dementia. MMSE Mini-Mental State Examination score, ACE Addenbrooke’s Cognitive Examination score. Mean difference [CI] difference of mean values between groups and 95 % confidence interval of the difference. p p-values of difference calculated by two-sided t-tests or Fisher’s exact test (Gender), n.s. nonsignificant (p > 0.05)