miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia – an exploratory study

Table 1 Demographic data of the patients included

Variable	Control group (range)	AD group (range)	Mean difference (CI)	p
Number	10	10
Gender (female/male)	4/6	6/4		n.s.
Age (years)	69.4 (54–79)	70.0 (56–82)	0.6 (−8.7;9.8)	n.s.
Duration (years)	2.8 (1.0-5.5)	2.3 (1.5-4.0)	−0.5 (−1.9;0.9)	n.s.
MMSE	24.1	21.4	−2,7 (−8.1;2.7)	n.s.
ACE	75.4	67.3	−8.1 (−18.0;1.7)	n.s.
Aβ1-42 [pg/ml CSF]	561.4 (315–865)	391.6 (242–755)	−169.8 (−330.0;-9.6)	0.04
Total tau [pg/ml CSF]	481.4 (228–1200)	540.6 (371–742)	59.2 (−223.3;341.7)	n.s.
P-tau [pg/ml CSF]	60.1 (31–148)	82.6 (55–110)	22.5 (−3.2;48.2)	n.s.

Control group patients diagnosed with vascular dementia (n = 4), frontotemporal dementia (n = 4), and dementia with Lewy bodies (n = 2). AD group patients all diagnosed with Alzheimer’s dementia. MMSE Mini-Mental State Examination score, ACE Addenbrooke’s Cognitive Examination score. Mean difference [CI] difference of mean values between groups and 95 % confidence interval of the difference. p p-values of difference calculated by two-sided t-tests or Fisher’s exact test (Gender), n.s. nonsignificant (p > 0.05)

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