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Table 1 Demographic data of the patients included

From: miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia – an exploratory study

Variable

Control group (range)

AD group (range)

Mean difference (CI)

p

Number

10

10

  

Gender (female/male)

4/6

6/4

 

n.s.

Age (years)

69.4 (54–79)

70.0 (56–82)

0.6 (−8.7;9.8)

n.s.

Duration (years)

2.8 (1.0-5.5)

2.3 (1.5-4.0)

−0.5 (−1.9;0.9)

n.s.

MMSE

24.1

21.4

−2,7 (−8.1;2.7)

n.s.

ACE

75.4

67.3

−8.1 (−18.0;1.7)

n.s.

Aβ1-42 [pg/ml CSF]

561.4 (315–865)

391.6 (242–755)

−169.8 (−330.0;-9.6)

0.04

Total tau [pg/ml CSF]

481.4 (228–1200)

540.6 (371–742)

59.2 (−223.3;341.7)

n.s.

P-tau [pg/ml CSF]

60.1 (31–148)

82.6 (55–110)

22.5 (−3.2;48.2)

n.s.

  1. Control group patients diagnosed with vascular dementia (n = 4), frontotemporal dementia (n = 4), and dementia with Lewy bodies (n = 2). AD group patients all diagnosed with Alzheimer’s dementia. MMSE Mini-Mental State Examination score, ACE Addenbrooke’s Cognitive Examination score. Mean difference [CI] difference of mean values between groups and 95 % confidence interval of the difference. p p-values of difference calculated by two-sided t-tests or Fisher’s exact test (Gender), n.s. nonsignificant (p > 0.05)