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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models

Fig. 5

Loss of DA neurons in the SNc of Pitx3–tTA::tetO–SNCA bigenic mice. a Sample images show the staining of TH (brown) in the SNc of 16–month–old Pitx3–tTA heterozygous knock-in and Pitx3–tTA::tetOSNCA bigenic mice. Scale bar: 100 μm. b Scatter plot depicts the number of remaining TH–positive neurons in the SNc of 1 month and 16–18 months. Data were presented as mean ± SEM. ***P < 0.001

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