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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models

Fig. 1

No propagation of α-syn into the nigrostriatal DA neurons of tetO–SNCA single transgenic mice. a Sample images show the expression pattern of hα-syn (green) in the sagittal sections of 1–month–old tetOSNCA mice. DA neurons were marked by TH staining (red). Topro3 was used for counter–staining (blue). CX; cerebral cortex; HIP: hippocampus; CB: cerebellum; STR: striatum; SNc: substantia nigra pars compacta. Scale bar: 1 mm. b Sample images show the staining of hα-syn (green) and TH (red) in the SNc of 1– and 18–month–old tetO–SNCA mice. Insets highlight the boxed area. Arrowheads point to the hα-syn–positive puncta. SNr: substantia nigra pars reticulata. Scale bar: 100 μm. c Sample images show the staining of m/hα-syn (green) and TH (red) in the SNc of 18–month–old tetO–SNCA single transgenic and Pitx3–tTA heterozygous knock-in mice. Arrowheads point to the hα-syn–positive puncta. Scale bar: 10 μm

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