Fig. 3

Short latency afferent inhibition in Parkinson’s diseasepatients with subthalamic nucleus deep brain stimulation. The abscissa indicates the different experimental conditions. The ordinate indicates the degree of short latency afferent inhibition. It represents the amplitude of paired-pulse induced MEP expressed as a ratio of the MEP amplitude induced by test alone. Values more than 1 indicate facilitation and those less than 1 indicate inhibition. * p < 0.05, comparing patients at ON medication OFF stimulation state to healthy controls and patients at ON medication ON stimulation state. The ring asterisks above the columns represent significant inhibition compared to test alone. Note that short latency afferent inhibition was normal in Parkinson’s disease patients at OFF medication state while it was reduced at ON medication state. Reduced inhibition at the ON medication state was normalized by the deep brain stimulation. MEP = motor evoked potential. Modified from Sailer et al., Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease, Neurology 2007, 68:356-363 [34]. Promotional and commercial use of the material in print, digital or mobile device format is prohibited without the permission from the publisher Wolters Kluwer Health. Please contact healthpermissions@wolterskluwer.com for further information